Table 1.
Clinical features of patients with ERBB2 somatic mutations including ERBB2 amplifications in Geneplus cohort
| Characteristics | n = 1281 |
|---|---|
| Age, years | |
| Mean (SD) | 56.8 (13.2) |
| Median (min-max) | 58 (18-89) |
| Gender, n (%) | |
| Male | 577 (45.0) |
| Female | 704 (55.0) |
| Smoking, n (%) | |
| Never | 479 (70.9) |
| Ever | 197 (29.1) |
| Unknown | 605 (100) |
| Tumor stage, n (%) | |
| I | 68 (19.0) |
| II | 25 (7.0) |
| III | 42 (11.7) |
| IV | 223 (62.3) |
| Unknown | 923 (100) |
| Histology, n (%) | |
| Adenocarcinoma | 1068 (94.9) |
| Squamous cell carcinoma | 46 (4.1) |
| Adenosquamous carcinoma | 8 (0.7) |
| Sarcomatoid carcinoma | 2 (0.2) |
| Neuroendocrine neoplasms | 1 (0.1) |
| Unknown | 156 (100) |
| Sample type, n (%) | |
| Tissue | 1155 (90.1) |
| Blood | 97 (7.6) |
| Pleura effusion | 24 (1.9) |
| Others | 5 (0.4) |
| Panel, n (%) | |
| 1021 | 663 (51.7) |
| 73 | 371 (29.0) |
| 36 | 132 (10.3) |
| Others | 115 (9.0) |