Table 3.
Logistic regression analysis on baseline features predicting aneurysmal dilatation.
| Univariate | Multivariable (1) | Multivariable (2) | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Male | 0.73 (0.24–2.2) | 0.577 | ||||
| Age (per 10 years increase) | 1.41 (0.78–2.54) | 0.256 | ||||
| Hypertension | 0.85 (0.27–2.61) | 0.771 | ||||
| Diabetes | 3.64 (0.22–61.68) | 0.370 | ||||
| Hyperlipidemia | 0.70 (0.15–3.25) | 0.646 | ||||
| Smoking | 0.47 (0.13–1.77) | 0.267 | ||||
| Old CVA | 0.47 (0.01–15.11) | 0.671 | ||||
| Family history | 0.57 (0.12–2.59) | 0.465 | ||||
| Initial symptom | ||||||
| Ischemic symptom | 1(Ref) | 1(Ref) | 1(Ref) | |||
| Headache | 10.11 (2.86–35.78) | < 0.001* | 2.45 (0.37–16.08) | 0.35 | 2.89 (0.50–16.79) | 0.237 |
| VW-MRI | ||||||
| Dissecting flap | 0.57 (0.13–2.47) | 0.455 | ||||
| Double lumen | 2.32 (0.76–7.06) | 0.139 | ||||
| Intramural hematoma | 0.17 (0.04–0.66) | 0.011* | 0.40 (0.04–4.02) | 0.437 | 0.27 (0.04–1.88) | 0.187 |
| Increased outer diameter | 69.58 (10.76–449.83) | < 0.001* | 26.08 (3.96–171.89) | < 0.001* | ||
| Onion-like appearance | 1.11 (0.34–3.61) | 0.867 | ||||
| Wall enhancement | 3.25 (0.88–11.96) | 0.077 | ||||
| Preserved patency | 5.23 (0.86–31.75) | 0.072 | ||||
| Eccentricity index (per 0.1 unit increase) | 0.88 (0.78–0.99) | 0.036* | ||||
| Remodeling index | 1.38 (1.02–1.87) | 0.034* | ||||
| Normalized wall index (per 0.1 unit increase) | 1.33 (0.87–2.05) | 0.190 | ||||
| RsIMH | 0.63 (0.35–1.13) | 0.120 | ||||
| TOF-MRA | ||||||
| Dissecting flap | 1.76 (0.52–5.96) | 0.363 | ||||
| Double lumen | 2.44 (0.69–8.66) | 0.167 | ||||
| Intramural hematoma | 0.94 (0.31–2.83) | 0.910 | ||||
| Increased outer diameter | 19.69 (4.93–78.71) | < 0.001* | 11.53 (2.18–60.84) | 0.004* | ||
| Preserved patency | 3.68 (0.85–15.99) | 0.082 | ||||
| Remodeling index | 1.54 (1.08–2.19) | 0.017* | 1.34 (0.67–2.68) | 0.408 | 1.42 (0.77–2.62) | 0.261 |
| rsIMH | 1.46 (0.80–2.67) | 0.217 | ||||
VW-MRI vessel wall magnetic resonance image; TOF-MRA time of flight-magnetic resonance angiography; OR odds ratio; CI confidential interval; CVA, cerebrovascular accident; rsIMH,relative signal intensity of intramural hematoma. Multivariable analysis was performed with two separate models to address the issue of multicollinearity involving the variable ‘increased outer diameter.’ In the first model, the variable of increased outer diameter on TOF-MRA was excluded. In the second model, the variable of increased outer diameter on VW-MRI was excluded. * indicates statistical significance (P < 0.05).