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. 2024 Oct 1;15:8487. doi: 10.1038/s41467-024-52793-6

Fig. 8. Comparison of mouse pharmacokinetic data for paclitaxel.

Fig. 8

a Plasma concentrations of paclitaxel were measured over 24 h. Paclitaxel was administered intravenously in a DMSO-based formulation whereas the Sol-paclitaxel analogs 8i, 8vi and the paclitaxel formyl phosphate prodrug 8vii were all dosed via oral gavage in saline solution. n = 3 mice per dose group. Line data represents mean values at each time point. b Comparison of oral bioavailability between Sol-paclitaxel 8vi and paclitaxel possessing a formyl phosphate prodrug 8vii. n = 3 mice per dose group. Data are presented as mean values +/− SD. Statistical significance was determined using an ordinary one-way ANOVA with Tukey’s multiple comparison test. Mouse image Created in BioRender. Smith, M. (2024) BioRender.com/y69d862.