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. 2024 Oct 1;15:8482. doi: 10.1038/s41467-024-52752-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — A A low-resolution C5 map of the DEV mature virion visualized from the bottom of the tail apparatus shows density for five appendages protruding from the collar and assigned to the tail fibers gp53. B A C15 symmetrized density of the DEV collar is visualized at a high contour (5σ). Fifteen copies of gp53-NTB were real-space refined against the C15 density. Only three NTB subunits (labeled ‘a-c’) are shown in the zoom-in panel. C A 90° rotated view of the three gp53-NTBs is shown in panel (B), which also includes an AlphaFold model of the gp53 flexible linker (res. 92-114), colored red, and the first part of the coiled-coil domain. D Schematic diagram of the proposed 12:15:pseudo-5 symmetry mismatch between DEV dodecameric HT-adapter gp83 (light pink circles) and 15 copies of gp53 NTB (gray/purple circles). A flexible linker in gp53 spanning residues 92–114 (shown as a red dotted line) allows three neighboring gp53 protomers to assemble into five trimeric long tail fibers that project outward. The boxed gp53 trimer at the bottom of panel (D) is shown in the same orientation as the AlphaFold model in panel (C).