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. 2024 Oct 1;15:8511. doi: 10.1038/s41467-024-52860-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a View of the PInC assembly colored by subunits. XPG, XPF/ERCC1, p62, and DNA are shown in cartoon representation. TFIIH, XPA, and RPA are shown in surface representation. The lesion containing DNA strand is shown in cyan; the undamaged strand is shown in blue. b Domain organization of the PInC constituent proteins XPG, XPF, ERCC1, XPA, RPA, XPB, XPD, and p62 mapped onto their respective sequences. Abbreviations denote H.W.—hydrophobic wedge; GH—gateway helix; CH—coiled-coil helix; H2TH—helix-2-turn-helix; H.D.—helicase domain; HhH—helix-hairpin-helix; DRD—damage recognition domain; NTE—N-terminal extension. c Schematic showing the DNA substrate of PInC, the length of the NER bubble, and the positions of the lesion site (red star) and the two incision sites (red scissor symbols).