Fig. 7. Human disease mutations mapped onto the PInC model are shown to localize at key community interfaces.

a Missense disease mutations mapped onto the sequences of XPG, XPA, and XPF. Disease phenotypes are labeled as XP, XP/CS, TTD, and XP/TTD and identified by symbols and color. b Map of human disease mutations (spheres) onto the PInC structure (anterior view) shown in cartoon representation and colored by community. The three primary clusters of mutations associated with XPG, TFIIH, and XPA are outlined with black dashed lines. c Map of human disease mutations onto the PInC structure shown in posterior view. d Close-up view of mutations within XPG. e Close-up view of mutations within XPA and XPF.