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. 2024 Oct 1;16(1):2410475. doi: 10.1080/19490976.2024.2410475

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — Gut microbiota transplant from chemotherapy-treated to germ-free mice recapitulates many phenotypic markers of bile acid dysregulation. (a) Hepatic Hal’s bile stain for bilirubin (marker of bile accumulation). Positive staining is green to brown in color. (b) Hepatic trichrome stain for collagen (marker of fibrosis). Positive staining is blue. (c) Serum LPS binding protein concentration. (d) Hepatic relative expression of genes involved in BA and xenobiotic metabolism, BA transport, BA sensing, and lipid metabolism. (e) Ileal expression of BA receptors and chemo-metabolizing gene Cyp3a13. (f) Distal colonic expression of BA receptors and proliferation marker Ki67. (a-f) N = 18 (vehicle-gmt n = 9, chemo-gmt n = 9), *p < 0.05. GMT = gut microbiota transplant.