Table 3.

Odd ratio for gestational diabetes mellitus in BCAAs and mTOR

		Model 1		Model 2		Model 3
BCAAs and mTOR levels	N(case/control)	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Val
T1 (< 149.94μmol/L)	21/24	1.00 (Ref)	-	1.00 (Ref)	-	1.00 (Ref)	-
T2 (149.94–176.37μmol/L)	28/16	0.500 (0.214–1.168)	0.109	0.498 (0.211–1.177)	0.112	0.377 (0.149–0.954)	0.039
T3 (≥ 176.37μmol/L)	17/26	1.338 (0,574–3.120)	0.500	1.217 (0.533–3.030)	0.589	1.154 (0.473–2.818)	0.753
P for trend			0.073		0.092		0.041
Leu
T1 (< 116.69μmol/L)	19/25	1.00 (Ref)	-	1.00 (Ref)	-	1.00 (Ref)	-
T2 (116.69–144.43μmol/L)	29/15	0.393 (0.166–0.932)	0.034	0.382 (0.160–0.915)	0.031	0.322 (0.129–0.811)	0.016
T3 (≥ 144.43μmol/L)	18/26	1.098 (0.471–2.580)	0.829	1.016 (0.426–2.424)	0.972	0.760 (0.302–1.909)	0.559
P for trend			0.038		0.046		0.043
Ile
T1 (< 66.03μmol/L)	23/21	1.00 (Ref)	-	1.00 (Ref)	-	1.00 (Ref)	-
T2 (66.03–95.41μmol/L)	23/23	1.000 (0.433–2.308)	1.000	1.026 (0.440–2.390)	0.953	0.997 (0.409–2.431)	0.995
T3 (≥ 95.41μmol/L)	20/24	1.314 (0.569–3.038)	0.523	1.286 (0.551–3.000)	0.561	1.058 (0.433–2.582)	0.902
P for trend			0.762		0.815		0.989
mTOR
T1 (< 17.84ng/ml)	47/20	1.00 (Ref)	-	1.00 (Ref)	-	1.00 (Ref)	-
T2 (17.84–20.13ng/ml)	6/29	11.358 (4.084–31.593)	< 0.001	12.344 (4.290–35.515)	< 0.001	11.771 (3.949–35.083)	< 0.001
T3 (≥ 23.13ng/ml)	13/17	3.073 (1.260–7.497)	0.014	4.200 (1.595–11.061)	0.004	4.869 (1.742–13.611)	0.003
P for trend			< 0.001		< 0.001		< 0.001

Model 1: unadjusted confounders, Model 2: adjusted for age, pre-pregnancy BMI. Model 3: further adjusted for HDL-C, LDL-C and TG, based on Model 2. P for trend was calculated by treating tertiles as ordinal predictors in multivariate conditional logistic regression

Abbreviation: BCAAs Branched chain amino acids, mTOR mammalian target of rapamycin, Val valine, Ile isoleuline, Leu leucine, T1 the first tertile, T2 the second tertile, T3 the third tertile, OR odds ratio, CI confidence interval, Ref reference