Fig. 1 |. Genomic loci associated with the nine BAGs.

Organ-specific BAG was derived from a large cohort of 30,108 to 111,543 participants of European ancestry from the UKBB cohort. The nine organ systems include the brain (N = 30,108), cardiovascular (N = 111,543), eye (N = 36,004), hepatic (N = 111,543), immune (N = 111,543), metabolic (N = 111,543), musculoskeletal (N = 111,543), pulmonary (N = 111,543) and renal (N = 111,543) BAGs. In total, 393 genomic loci–BAG pairs were identified using a genome-wide P value threshold (−log₁₀ (P value) > 7.30; two sided). For visualization purposes, we denoted the genomic loci using their top lead SNPs that are not associated with any clinical traits in the EMBL-EBI GWAS Catalog. All analyses used GRCh37. We present representative features used in calculating each organ’s BAG; BMI, body mass index; Chr, chromosome; IDP, imaging-derived phenotype; GM, gray matter; WM, white matter; FC, functional connectivity; OCT, optical coherence tomography; FVC, forced vital capacity; FEV, forced expiratory volume; PEF, peak expiratory flow. The human anatomy was created with BioRender.com.