Fig. 6. Binge Ethanol Exposure in Advanced Age Contributes to Impaired Contextual Memory.
(A) The contextual fear conditioning (CFC) paradigm used on Days 20 and 21. (B) The average time of freezing behavior (seconds) was measured over 5 minutes on Day 20 of the CFC. Lightning bolts indicate time of shock. (C) Average freezing behavior of all treatment groups over 5 minutes on Day 21. Animals were not subjected to foot shocks on Day 21. Mean and SEM are reported, values were significantly different from each other determined by repeated measures ANOVA with Geisser-Greenhouse correction and Tukey’s post hoc test * p < 0.001 of the aged ethanol group compared to all other treatment groups determined by repeated measures ANOVA with Geisser-Greenhouse correction and Tukey’s post hoc test.