Figure 7.

CNPY2 protein levels are altered in the N171-82Q mouse brain. Brain tissues were prepared from control and N171-82Q mice of different ages and used for immunoblotting with anti-CNPY2 antibodies as described in methods. GAPDH was used as control for the immunoblots. Left, immunoblot. Right, quantification. Upper panels, striatum. Note increases in CNPY2 in 10–16 weeks old N171-82Q mice compared with age-matched controls. Lower panels, cortex. CNPY2 was increased particularly in the 16-week-old N171-82Q mice compared with control mice. Quantification was done separately for the 21 kDa and the 17 kDa CNPY2 band. Values are means ± SD, n = 5. ^*p < 0.05 for N171-82Q samples vs. control samples.