Table 2. Univariate and multivariate analyses for OS and RFS in the HCC cohort.
*P < 0.05. HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; MVI, microvascular invasion; TNM, tumor-nodes-metastasis; BCLC, Barcelona Clinic Liver Cancer.
| Variable | OS | RFS | ||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||
| P value | HR (95% CI) | P value | P value | HR (95% CI) | P value | |
| Age, years (>65 versus ≤65) | 0.1035 | 0.6089 | ||||
| Gender (male versus female) | 0.8522 | 0.6201 | ||||
| HbsAg (positive versus negative) | 0.0490* | 2.5 (1.2–5.3) | 0.020* | 0.2139 | ||
| AFP, ng/ml (>400 versus ≤400) | 0.0103* | 0.0076* | ||||
| Cirrhosis (present versus absent) | 0.0526* | 0.1682 | ||||
| Ascites (present versus absent) | 0.3934 | 0.0541* | ||||
| Tumor size, cm (>5 versus ≤5) | 0.0261* | 0.1057 | ||||
| Tumor number (multiple versus single) | 0.2267 | 0.0044* | 2.5 (1.5–4.2) | 0.001* | ||
| Tumor encapsulation (absent versus present) | 0.1917 | 0.0302* | 2.4 (1.1–5.0) | 0.025* | ||
| Tumor differentiation (III and IV versus I and II) | 0.6205 | 0.6489 | ||||
| Vascular invasion (present versus absent) | <0.0001* | <0.0001* | ||||
| MVI (present versus absent) | 0.0088* | 0.0472* | ||||
| TNM stage (III and IV versus I and II) | 0.0021* | 0.0005* | ||||
| BCLC stage (B + C versus 0 + A) | 0.0067* | 2.5 (1.7–3.6) | <0.0001* | 0.010* | 1.9 (1.4–2.7) | <0.0001* |
| NOD1+CD68+cell (high versus low) | 0.0188* | 0.5 (0.3–0.9) | 0.036* | 0.0224* | 0.5 (0.3–0.8) | 0.005* |