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Schematic representation of three different types of ELISA for characterizing the anti-RBD humoral response elicited by SARS-CoV-2 infection. (a) RBD ELISA set up for detecting recognition and binding of convalescent IgG antibodies to RBD. (b) Surrogate virus neutralization test (sVNT) design for evaluating the inhibitory capacity of anti-RBD IgG antibodies in blocking the binding of RBD-ACE2. (c) RBD avidity ELISA set up for estimating the IgG avidity of IgG antibodies against RBD.
