Skip to main content
. 2024 Jul 15;15(5):1772–1784. doi: 10.1002/jcsm.13529

Figure 2.

Figure 2

Acute deletion of Trp53 in myofibres increases energy expenditure and locomotor activity. (A) Oxygen consumption (VO2) and average maximal oxygen consumption (VO2 max; right panel) in light/dark phase of control mice carrying lox‐P elements on both alleles but do not carry a CreERT2‐allele (LOX; black line /white bars) and p53MKO (blue line/blue bars) mice after 5‐day tamoxifen exposure and 2‐day recovery. (B) Energy expenditure (EE) and average maximal energy expenditure (EE max; right panel) in light/dark phase of control and p53MKO mice. (C) Activity counts expressed as XT + YT movements and sum of activity counts (XT + YT; right panel) in light/dark phase in control and p53MKO mice. (D) Protein levels of phosphorylated‐CaMKII (T286) and pan‐CaMKII in quadriceps muscle, with quantification of p‐CaMKII (T286) relative to pan‐CaMKII, normalized to total protein loading. Results presented as mean ± SEM and compared by t‐test with Welch's correction, or multiple t‐testing (n = 14 for A–C; n = 8–10 for D); *P < 0.05, **P < 0.01.