Figure 6.

Acute Trp53 deletion in myofibres leads to rapid and transient metabolic adaptations. (A) Respiratory exchange ratio (RER), (B) carbohydrate oxidation, (C) activity counts measured as XT + YT movements in control (black line) and p53MKO (blue line) animals with ad libitum food access during 8 days' tracing energy metabolism changes during induced Trp53 inactivation. Red arrows indicate days of tamoxifen administration. Results presented as mean ± SEM and were compared by multiple t‐tests (n = 4–5); *P < 0.05, **P < 0.01.