FIGURE 8.

p53MKO mice exhibit reduced exercise capacity and metabolic inflexibility. (A) Total distance of run, duration of run, and final velocity at point of exhaustion comparing control (LOX; white bars) and p53MKO (KO; green bars) mice undergoing an acute endurance treadmill running bout until exhaustion. (B) Percent fuel utilization of control animals (upper panel), depicting percentage of lipid (black line) and CH oxidation (grey line), and p53MKO animals (lower panel; lipid: blue line; CH: red line). The point of crossover, at which lipid and CH fuel utilization are equal, is represented by the vertical dashed lines. (C) Time at sustained first crossover point in control (white bar) and p53MKO (green bar) mice. (D) Plasma glucose levels of control and p53MKO mice after acute endurance running. (E) mRNA expression of Slc2a4 in quadriceps and gastrocnemius of control and p53MKO mice after acute endurance exercise. Results presented as mean ± SEM and analysed by t‐test with Welch's correction (n = 4 in B, C; n = 9–14 in a, D, E); *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.