Figure 3.

JAK2 and SKAP2 are the main drivers and ZDBF2 and ARHGAP11B are top targets in aged muscle based on GSE9419 dataset. (A) Thickness represents the interaction strength, arrows the directionality, the most influencing genes (i.e., drivers) are in blue and the main influencers (i.e., targets) are depicted as orange in the interactome map. (B–D) Charts generated by Metacore depicting top 10 overrepresented gene ontology GO cellular processes (B), process networks (C), and pathway maps (D) in aged versus young adults. (E, F) Metascape was used to create bar graphs indicating most significantly enriched biological processes (E) and networks clusters of GO terms (F) in age responsive genes with the strongest interactions as a result of ANNI analysis.