Figure 2.

Summary of pathways related to sarcopenia and metabolite‐metabolite interaction network analysis. (A) Network pathway was identified by MetaboAnalyst. Metabolism was inferred from changes in levels of intermediates during substance metabolism in plasma. (B) Cellular enrichment analysis of interaction between changed metabolites and the enzymes. (C) Network pathways were identified by MetaboAnalyst software. Network analysis of differentially expressed metabolites was performed by ingenuity pathway tools (www.ingenuity.com) on metabolites annotated in the ingenuity database. Significant changes in amino acid metabolism, molecular transport, inflammatory response, free radical scavenging, and lipid metabolism, as well as PI3K‐AKT signalling, mTOR signalling, and ERK/MAPK signalling network were identified.