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Clinical implication of Hispanic population difference in clearance. Hispanics and Whites receiving 0.1 mg/kg/day as initial dose and following hospital’s dose titration strategy for the first week of treatment. Target range is 10–12 ng/mL and safety level is 15 ng/mL. Data were simulated using the developed popPK model to simulate 100 patients from the Hispanic population and 100 patients using the 23.5 L/h clearance, representative of “White” populations from literature.
