Skip to main content
. 2024 Sep 2;56(9):1980–1990. doi: 10.1038/s12276-024-01298-9

Fig. 6. Targeting STAT3 alleviates NLRP3-associated inflammation.

Fig. 6

a, b Wild-type C57BL/6 mice were administered DMSO or napabucasin (5 mg/kg) via intraperitoneal (i.p.) injection 30 min before i.p. injection of MSU (2 mg per mouse) (n = 5 biologically independent mice) for 6 h. Quantification of neutrophils (a) and ELISA of IL-1β secretion (b) in the peritoneal lavage fluid. c–e Wild-type C57BL/6 mice were administered 20 mg/kg LPS via intraperitoneal (i.p.) injection (n = 5 biologically independent mice) for 8 h with or without napabucasin (5 mg/kg). ELISA results showing the serum concentrations of IL-1β (c) and IL-6 (d) and images of H&E-stained lung tissue sections (e). Scale bar: 50 μm. The data are representative of three independent experiments. The results are presented as the means ± SEMs. Statistical analyses were carried out via two-way ANOVA in (a–d). *P < 0.05, **P < 0.01 and ***P < 0.001.