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. 2024 Oct 2;14:406. doi: 10.1038/s41398-024-03098-1

Fig. 1. Schematic overview of the four-folded approach.

Fig. 1

Our analyses systematically characterize the eleven antagonistic SNPs with regard to their link to brain structure and brain-related traits: In (1) we perform a SNP to brain image-derived phenotype (IDP) analysis. In (2) we investigate if implicated IDPs are altered in patients with neuropsychiatric disorders compared to controls using the ENIGMA datasets. In (3) we assess if antagonistic SNPs are part of eQTLs for brain tissue, and if antagonistic SNPs are associated with additional cognitive and behavioral traits. In (4) we investigate if there are further associations of the antagonistic SNPs with brain structure at the voxel-wise level that might have been missed in the SNP-to-IDP analysis. SNP single-nucleotide polymorphism.