Table 1.
Statistics of the significant associations between eight antagonistic SNPs and IDPs.
| rsID | CHR | BP | EA/OA | Risk | Prot. | IDP | CT/SA/Vol. | p-value | pFDR-value | Effect |
|---|---|---|---|---|---|---|---|---|---|---|
| rs2388334 | 6 | 98591622 | A/G | TS | ASD | Transverse temporal | SA | 2.16 × 10−05 | 3.13 × 10−03 | 1.643 |
| BIP | Banks of sts. | SA | 2.89 × 10−05 | 3.14 × 10−03 | −3.548 | |||||
| Insula | SA | 6.04 × 10−04 | 2.50 × 10−02 | 4.445 | ||||||
| Inferior parietal | SA | 1.50 × 10−03 | 4.83 × 10−02 | −10.312 | ||||||
| rs301805 | 1 | 8481016 | T/G | MDD | SCZ | Caudal ant. cingulate | SA | 7.09 × 10−04 | 2.80 × 10−02 | −2.571 |
| Insula | SA | 1.00 × 10−03 | 3.62 × 10−02 | 4.277 | ||||||
| Posterior cingulate | CT | 1.05 × 10−03 | 3.65 × 10−02 | 0.003 | ||||||
| rs75595651 | 4 | 123133540 | T/C | BIP | MDD | Rostral ant. cingulate | CT | 2.87 × 10−05 | 3.14 × 10−03 | 0.013 |
| Frontal pole | SA | 7.88 × 10−05 | 5.71 × 10−03 | 2.018 | ||||||
| Caudal ant. cingulate | CT | 2.16 × 10−04 | 1.24 × 10−02 | 0.013 | ||||||
| rs3142801 | 6 | 105365891 | A/G | SCZ | MDD | Pericalcarine | SA | 5.39 × 10−05 | 4.68 × 10−03 | −6.217 |
| Lingual | SA | 4.68 × 10−04 | 2.03 × 10−02 | −8.131 | ||||||
| Caudate | Vol. | 1.39 × 10−03 | 4.64 × 10−02 | 3.197 | ||||||
| rs6748341 | 2 | 225377574 | C/G | SCZ | ANO | Pars opercularis | SA | 7.55 × 10−05 | 5.71 × 10−03 | 5.788 |
| rs3806843 | 5 | 140212538 | T/C | SCZ | MDD | Putamen | Vol. | 1.64 × 10−05 | 3.13 × 10−03 | −4.310 |
| Caudate | Vol. | 2.10 × 10−05 | 3.13 × 10−03 | −4.254 | ||||||
| Nucleus accumbens | Vol. | 3.10 × 10−04 | 1.58 × 10−02 | −3.607 | ||||||
| rs9329221 | 8 | 10240202 | T/G | SCZ | ASD | Superior temporal | SA | 7.93 × 10−12 | 6.89 × 10−09 | −12.496 |
| Transverse temporal | SA | 1.33 × 10−05 | 3.13 × 10−03 | −1.707 | ||||||
| Isthmus cingulate | SA | 2.04 × 10−04 | 1.24 × 10−02 | 3.264 | ||||||
| Supramarginal | CT | 3.84 × 10−04 | 1.77 × 10−02 | 0.002 | ||||||
| Lateral orbitofrontal | SA | 3.87 × 10−04 | 1.77 × 10−02 | 5.045 | ||||||
| Posterior cingulate | SA | 8.46 × 10−04 | 3.19 × 10−02 | −2.924 | ||||||
| rs2921036 | 8 | 8363897 | T/C | ASD | SCZ | Superior temporal | SA | 1.11 × 10−08 | 4.82 × 10−06 | 10.374 |
| Transverse temporal | SA | 3.46 × 10−05 | 3.34 × 10−03 | 1.615 | ||||||
| Lateral orbitofrontal | SA | 1.20 × 10−04 | 8.02 × 10−03 | −5.439 | ||||||
| Brainstem | Vol. | 2.28 × 10−04 | 1.24 × 10−02 | 3.685 |
EA refers to the effect allele of disorder risk (increased risk or protective effect) [24] as well as the effect allele in relation to the p-value and effect size, which were taken from summary statistics of the respective GWAS of brain phenotypes [35, 38, 41]. The effect is given as β for cortical IDPs and as Z-scores for subcortical IDPs. 1Note that we replaced rs1933802 using the proxy rs314280 as described in the Materials and Methods.
ANO anorexia nervosa, ant. anterior, ASD autism spectrum disorder, BIP bipolar disorder, CT cortical thickness, EA effect allele, FDR false discovery rate, IDP image-derived phenotype, MDD major depressive disorder, OA other allele, Prot. protective, SA surface area, SCZ schizophrenia, SNP single-nucleotide polymorphism, sts. superior temporal sulcus.