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. 2024 Jul 5;67(10):2260–2274. doi: 10.1007/s00125-024-06207-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — tRFs of CD4⁺/CD25⁻ T cells transferred in vitro and in vivo to pancreatic beta cells. (a) Real-time PCR of islet cell tRFs pulled down on streptavidin beads upon incubation with EVs released by EU-treated T cells (EU-EVs) or untreated control T cells (CTRL-EVs). An EU-tagged C. elegans miR-238 mimic was spiked in cell extracts as internal control. *p<0.05, **p<0.01 (ratio paired t test). (b) EU-tagged RNAs from FAC-sorted beta cells of NOD.SCID mice injected with EU-tagged T cells (EU) or with saline solution (CTRL) were purified on streptavidin beads and analysed by qPCR. An EU-tagged oligonucleotide containing the sequence of C. elegans miR-238 was spiked in the samples and was used as internal control to normalise the data. Data are presented as mean ± SD. n=3–5. *p<0.05 (ratio paired t test)