(A) The most frequently discussed themes in flare-related posts by patients with ulcerative colitis,a (B) the most frequently discussed flare-related topics by patients with ulcerative colitis,a and (C) the top 12 ranked flare-related topics discussed by patients with ulcerative colitis.b Flare-related posts, including those from the same author pre- and postflare, were identified from posts written by patients with ulcerative colitis on 8 online public forums in 6 different countries due to the inclusion of keywords. Data were then mapped semantically. aFlare-related post data were color-coded by themes and topics; each node represents a post, and connections represent similar language used across the posts. Centrally located nodes represent core concepts and peripheral nodes represent niche concepts. Percentages represent total volume of posts. bTop topic rankings are a result of a combined weighted score of volume (40%), unique authors (20%), negative sentiment (15%), betweenness centrality (15%), and recency (10%). cJoint pain and fatigue were analyzed together due to the proportion of posts that mentioned both symptoms (approximately 20% of the 2.4% of posts). C. difficile, Clostridioides difficile.