Table 2.

Behavioral changes after application of drugs with the antidepressant-like effect to K⁺ channels in animal models of depression.

K+ channels	Subtypes	Behavioral changes
Kv	Kv1	Ketamine reverses LH by inhibiting Kv1 [39] Blockade of Kv1.4 by UK-78,282 increases the motivation for sucrose reward [134]
	Kv7	Upregulation of Ketamine on Kv7.2 lowers the immobility in FST, and improves the social and anxiolytic behaviors assessed by social box [80]; Kv7 opener ketamine induces an increase in SPT and reduces the immobility in FST [56]; activation of Kv7.4 by fasudil improve social interaction time and SPT [79]; opening of Kv7 by Lu AA41178 reduces the immobility in FST [78]
Kir	Kir4.1	Declined surface expression of Kir4.1 by ketamine in astrocytes improves the depressive behaviors in FST, LH and SPT [9, 130] Kir4.1 inhibitor Lys05 exerts rapid-onset antidepressant actions and releases the depressive-like behaviors in NST, FST and SPT [88]
	KATP	Inhibition of memantine on KATP lowers the immobility in FST and TST [135]; blockage of glibenclamide on KATP channels reduces the immobility in FST [111]; inhibition of gabapentin and baclofen on KATP channels declines the immobility in FST [114, 115]
K2P	TREK	Blockage of spadin and SID1900 on TREK-1 reverses the depressive-like behaviors assessed by FST, SPT, and open field tests [136] (or see the review by Borsotto et al. [124])

LH learned helplessness, FST the forced swim test, TST tail suspension test, SPT sucrose preference test, NSF novelty-suppressed feeding test.