Fig. 5. Computational modelling of the arterial wall revealed increased extracellular matrix stiffening after CPP1 incubation.

A Representative graph of the mathematical model fit for a thoracic descending aortic sample, treated with CPP1. B Aortic segments, treated with CPP1 for 24 h, increased (passive) wall stiffness as seen by an increase in β_{0, pas}. C–E No differences were observed in the other parameters. Statistical analysis was performed using a Two-Way ANOVA with a Sidak post hoc test for multiple comparisons. n = 9, except: E CPP1-infrarenal aorta; n = 7. *p < 0.05. Error bars represent standard error of the mean (SEM).