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Induction of neutralizing antibodies in guinea pigs by PLG/DNA formulation
| Inoculum | Dose (μg) | 50% Neutralization
|
90% Neutralization
|
||
|---|---|---|---|---|---|
| GMT | % Seropositive | GMT | % Seropositive | ||
| DNA | 250 | 35 | 100 | 14.6 | 100 |
| DNA/PLG | 250 | 74.5 | 100 | 24.9 | 100 |
| DNA/PLG/AlPO4 | 250 | 101.1 | 90 | 39.3 | 90 |
| DNA | 25 | 10.5 | 10 | <10 | 0 |
| DNA/PLG | 25 | 29.3 | 70 | 13.9 | 40 |
| DNA/PLG/AlPO4 | 25 | 49.8 | 100 | 16.7 | 75 |
| Protein/MF59 | 50 | 89.9 | 100 | 43.3 | 71.4 |
