TABLE 2.
Haemodynamic characteristics and pressure–volume loop analysis of BMPR2 carriers versus control group
| Control | BMPR2 carrier | p-value | |
|---|---|---|---|
| Participants (n) | 15 | 22 | |
| Age (years) | 40±12 | 45±16 | 0.273 |
| Female (%) | 11 (73) | 14 (64) | 0.794 |
| Haemodynamic parameters | |||
| mPAP (mmHg) | 14.1±4.3 | 16.5±2.3 | 0.036* |
| mRAP (mmHg) | 3.9±2.4 | 5.7±2.1 | 0.024* |
| PCWP (mmHg) | 7.0±2.7 | 10.4±3.1 | 0.001** |
| PVR (WU) | 0.9±0.5 | 1.1±0.5 | 0.168 |
| Cardiac output (L·min−1) | 8.1±1.5 | 5.7±1.2 | <0.001*** |
| Cardiac index (L·min−1·m−2) | 4.4±0.8 | 3.1±0.6 | <0.001*** |
| Pressure–volume relationship | |||
| Participants (n) | 15 | 14 | |
| Maximal pressure (mmHg) | 42±6 | 38±7 | 0.105 |
| RVEDV (mL) | 130±29 | 110±33 | 0.080 |
| RVESV (mL) | 52±13 | 45±19 | 0.249 |
| Stroke volume (mL) | 79±21 | 65±16 | 0.056 |
| Eed (mmHg·mL−1) | 0.19±0.06 | 0.20±0.13 | 0.846 |
| Ea (mmHg·mL−1) | 0.15±0.06 | 0.27±0.08 | <0.001*** |
| Ees (mmHg·mL−1) | 0.28±0.07 | 0.35±0.10 | 0.047* |
| RV coupling | 2.24±1.03 | 1.36±0.37 | 0.006** |
Data are presented as mean±sd, unless otherwise indicated. Control group is derived from a historical control group of healthy subjects. Ea: arterial elastance; Eed: end-diastolic elastance; Ees: end-systolic elastance; EDV: end-diastolic volume; ESV: end-systolic volume; mPAP: mean pulmonary arterial pressure; mRAP: mean right atrial pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; RV: right ventricular; WU: Wood unit. *: p<0.05; **: p<0.01; ***: p<0.001.