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. 2024 Sep 18;96(39):15765–15772. doi: 10.1021/acs.analchem.4c03871

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© 2024 The Authors. Published by American Chemical Society

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Rapid pacing of traveling wave promote maturation of hiPSC-derived cardiomyocytes (CMs). (A) Schematic and image describing the cell plating and traveling wave origination in the close-loop device. (B) Representative confocal images of cardiac tissue with or without traveling wave (TW) on day 14. CMs were stained with anti-α-actinin, anti-MYL2, anti-TnT2, anti-Cx43, anti-β-MHC, and DAPI. Transmission electron microscopy (TEM) analysis of cardiac tissue was performed for both the TW training and control groups on day 14.