Table 7. Noncompartmental Pharmacokinetic Parameter of HHC at Dose 40 mg/kg after Oral/IP Administration in Mice (n = 4).
| PK parameters | AUC0–t (ng·min/mL) | AUC0–∞ (ng·min/mL) | MRT0–t (min) | MRT0–∞ (min) | T1/2 (min) | Cmax (ng/mL) | Tmax (min) |
|---|---|---|---|---|---|---|---|
| oral-plasma | 7610.4 ± 1906.9 | 8545.1 ± 2044.9 | 96.8 ± 29.0 | 154.7 ± 49.6 | 130.2 ± 32.1 | 194.2 ± 43.5 | 15.0 ± 0.0 |
| IP-plasma | 61 967.7 ± 1759.6 | 62 838.2 ± 16 997.4 | 42.5 ± 28.7 | 52.5 ± 28.3 | 91.2 ± 15.3 | 9299.0 ± 4286.9 | 5.0 ± 0.0 |
| IP-liver | 572 497.7 ± 270 586.6 | 576 329.6 ± 272 103.4 | 156.2 ± 39.4 | 160.1 ± 35.8 | 104.5 ± 25.8 | 25 043.3 ± 12 061.5 | 5.0 ± 0.0 |
| IP-kidney | 37 213.4 ± 12 705.8 | 38 922.3 ± 14 659.8 | 96.3 ± 20.6 | 116.5 ± 37.4 | 101.7 ± 37.4 | 1703.0 ± 897.2 | 6.3 ± 2.5 |
| IP-brain | 1120.8 ± 439.8 | 1267.5 ± 507.2 | 62.9 ± 64.2 | 122.5 ± 91.9 | 106.1 ± 58.8 | 120.2 ± 54.1 | 5.0 ± 0.0 |
Area under the concentration–time curve (AUC) computed from time zero to the time of the last positive t value (AUC0–t); AUC from time zero extrapolated to infinity (AUC0–∞); mean residence time when the drug concentration is based on values up to and including the last measured concentration (MRT0–t); MRT from time zero extrapolated to infinity (MRT0–∞); elimination half-life (T1/2); maximum observed drug concentration (Cmax); and time of maximum concentration (Tmax). All of the HHC PK values are listed as the mean value ± SD. Each mean ± SD (n = 4) is represented by each point.