TABLE 2.
Adverse events in induction ABVD, additional ABVD, escalated BEACOPP.
| NCI‐CTCAE ver.4.0 | Induction ABVD (n = 92) | Additional ABVD (n = 73) | Escalated BEACOPP (n = 19) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any grade % | G3/4% | G3 | G4 | Any grade % | G3/4% | G3 | G4 | Any grade % | G3/4% | G3 | G4 | |
| Leukopenia | 83.7 | 46.7 | 33 | 10 | 83.6 | 47.9 | 26 | 9 | 100.0 | 100.0 | 0 | 19 |
| Neutropenia | 98.9 | 75.0 | 27 | 42 | 95.9 | 68.5 | 23 | 27 | 100.0 | 100.0 | 0 | 19 |
| Lymphocytopenia | 83.7 | 37.0 | 27 | 7 | 84.9 | 34.2 | 24 | 1 | 100.0 | 100.0 | 0 | 19 |
| Anemia | 43.5 | 2.2 | 2 | 0 | 45.2 | 2.7 | 2 | 0 | 68.4 | 57.9 | 10 | 1 |
| Thrombocytopenia | 23.9 | 1.1 | 1 | 0 | 9.6 | 1.4 | 0 | 1 | 100.0 | 94.7 | 7 | 11 |
| Bilirubin increased | 6.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| AST increased | 50.0 | 0 | 0 | 0 | 45.2 | 1.4 | 0 | 1 | 78.9 | 0.0 | 0 | 0 |
| ALT increased | 67.4 | 3.3 | 3 | 0 | 53.4 | 1.4 | 1 | 0 | 94.7 | 5.3 | 1 | 0 |
| Creatinine increased | 6.5 | 0 | 0 | 0 | 5.5 | 0 | 0 | 0 | 5.3 | 0 | 0 | 0 |
| Hyperglycemia | 16.3 | 0 | 0 | 0 | 20.5 | 1.4 | 1 | 0 | 21.1 | 0 | 0 | 0 |
| Hyponatremia | 23.9 | 0 | 0 | 0 | 13.7 | 1.4 | 1 | 0 | 21.1 | 5.3 | 1 | 0 |
| Hypokalemia | 2.2 | 0 | 0 | 0 | 2.7 | 0 | 0 | 0 | 36.8 | 10.5 | 2 | 0 |
| PN: sensory | 31.5 | 0 | 0 | 0 | 38.4 | 0 | 0 | 0 | 47.4 | 5.3 | 1 | 0 |
| PN: motor | 5.4 | 0 | 0 | 0 | 5.5 | 0 | 0 | 0 | 5.3 | 0 | 0 | 0 |
| Constipation | 8.7 | 0 | 0 | 0 | 32.9 | 0 | 0 | 0 | 31.6 | 0 | 0 | 0 |
| Diarrhea | 7.6 | 0 | 0 | 0 | 6.8 | 0 | 0 | 0 | 10.5 | 0 | 0 | 0 |
| Nausea | 72.8 | 1.1 | 1 | – | 65.8 | 2.7 | 2 | ‐ | 63.2 | 5.3 | 1 | – |
| Oral mucositis | 22.8 | 1.1 | 1 | 0 | 16.4 | 2.7 | 2 | 0 | 15.8 | 0 | 0 | 0 |
| Ileus | 1.1 | 1.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anorexia | 44.6 | 1.1 | 1 | 0 | 38.4 | 0 | 0 | 0 | 47.4 | 0 | 0 | 0 |
| Fever | 8.7 | 1.1 | 1 | 0 | 17.8 | 0 | 0 | 0 | 36.8 | 0 | 0 | 0 |
| Febrile neutropenia | 5.4 | 5.4 | 5 | 0 | 8.2 | 8.2 | 6 | 0 | 26.3 | 26.3 | 5 | 0 |
| Coughing | 4.3 | 0 | 0 | – | 6.8 | 1.4 | 1 | – | 10.5 | 0 | 0 | – |
| Dyspnea | 1.1 | 0 | 0 | 0 | 2.7 | 1.4 | 1 | 0 | 5.3 | 5.3 | 1 | 0 |
| Hypoxemia | 1.1 | 0 | 0 | 0 | 1.4 | 1.4 | 1 | 0 | 5.3 | 5.3 | 1 | 0 |
| Pneumonia | 1.1 | 0 | 0 | 0 | 5.5 | 1.4 | 1 | 0 | 0 | 0 | 0 | 0 |
| Any infections | 10.9 | 4.3 | 4 | 0 | 24.7 | 2.7 | 2 | 0 | 26.3 | 0 | 0 | 0 |