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. 2024 Aug 22;18(39):26614–26630. doi: 10.1021/acsnano.4c04814

Figure 6.

Figure 6

Evaluation of the therapeutic effect of novel drug-loaded systems in MI-induced cardiac insufficiency in mice. (a) Experimental protocol and dosing protocol of MI-induced mouse cardiac insufficiency model. (b) Representative plot of mouse cardiac ultrasound 30 days after the construction of the MI model. (c) Left ventricular ejection fraction quantified by echocardiography. (d) Left ventricular minor axis contraction (mean ± SD, n = 6). (e) Quantification of fibrotic area in the sham group, MI model group, and MI with different treatment group. (g) Representative cross sections from remote LV stained with Masson; scale bar = 100 μm. (f) Statistical plot of changes in cardiomyocytes area stained with WGA (mean ± SD, n = 6) and (h) representative LV cross-section stained with WGA, scale bar = 20 μm. *p < 0.05, **p < 0.01, and ***p < 0.001, one-way ANOVA, Tukey’s multiple comparison test.