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. 2024 Sep 6;18(39):26733–26750. doi: 10.1021/acsnano.4c06921

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© 2024 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Enrichment analysis of differential proteins between Met- and Ctrl-EVs. (A) Analysis of subcellular localization of differentially expressed proteins. (B) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the upregulated proteins. (C–E) Gene Ontology (GO) classification of the upregulated proteins in terms of biological processes, cellular components, and molecular functions. Met, metformin; Ctrl, control; EVs, extracellular vesicles; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, Gene Ontology.