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. 1985 Apr 1;227(1):13–20. doi: 10.1042/bj2270013

Characterization of a novel Na+-independent amino acid transporter in horse erythrocytes.

D A Fincham, D K Mason, J D Young
PMCID: PMC1144803  PMID: 3994678

Abstract

Horse erythrocytes are polymorphic with respect to L-alanine permeability. The present investigation compared the specificity, kinetics and cation-dependence of erythrocyte amino acid transport in two groups of thoroughbred horses, those with erythrocyte L-alanine permeabilities in the range 5-15 mumol/h per litre of cells (0.2 mM extracellular L-alanine, 37 degrees C) (transport-negative type) and those with L-alanine permeabilities in the range 450-700 mumol/h per litre of cells (transport-positive type). Transport-positive cells are shown to possess a novel high-affinity, stereospecific, Na+-independent transporter selective for neutral amino acids of intermediate size. This carrier system (provisional designation asc) operates preferentially in an exchange mode and is functionally absent from erythrocytes of transport-negative-type horses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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