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. 2024 Oct 3;12:28. doi: 10.1186/s40170-024-00357-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Differential gene expression analysis between PDOs from basal-like and classical tumors. (a) Volcano plot of differentially expressed genes between PDOs from basal-like and classical tumors. Expression in basal-like PDOs is shown in reference to classical PDOs. (b) Bar plots showing gene set enrichment analysis performed on up (top; red) and down (bottom; blue) regulated genes in basal-like PDOs compared to classical PDOs. Genes enriched in basal-like PDOs are belong to pathways that associate with aggressive tumors (c) Kaplan-Meier survival curves depicting association of median overall survival with gene expression quantiles in a cohort of PDAC metastatic biopsies (PanGen, n = 69)