TABLE 3.

Validation of the four selected gene signatures: discriminating patients with bacterial (n = 8) from viral and SARS-CoV-2 (n = 16) etiologies

Study	Sensitivity in % (95%CI)	Specificity in % (95%CI)	AUC (95%CI)	Accuracy in %
Xu et al.
2-gene signature   IFI44L, PI3	75.0 (34.9–96.8)	93.8 (69.8–99.8)	0.91 (0.78–0.1.00)	87.5
Li et al.
3-gene signature   HERC6, IGF1R, NAGK	87.5 (47.4–99.7)	93.8 (69.8–99.8)	0.97 (0.91–0.1.00)	91.7
Rao et al.
8-gene signature   EPI3, FCER1A, HESX1, ICAM1, IFI27, JUP, SMARCD3, SUCLG2	100.0 (63.1–100.0)	100.0 (79.4–100.0)	0.99 (0.99–1.00)	100.0
Ravichandran et al.
10-gene signature   DNMT1, EPSTI1, GYG1, HK3, IFI27, IFI44, ISG15, MMP9, MX1, PRF1	100.0 (63.1–100.0)	100.0 (79.4–100.0)	0.99 (0.99–1.00)	100.0