TABLE 1.
Cleavage site mutants used in this studya
| Mutant | Cleavage site(s) mutated | Source of mutants and/or references |
|---|---|---|
| pNL 4.3 | NIH reagent program | |
| MA/CA | Secondary | Pettit and Swanstrom, unpublished |
| CA/p2 | Tertiary | Pettit and Swanstrom, unpublished |
| p1/p6 | Secondary | Pettit and Swanstrom, unpublished |
| CA2 | Primary (p2/NC) | Wiegers et al. (36) |
| CA5 | Tertiary (CA/p2 and cryptic site) | Wiegers et al. (36) |
| CA6 | Primary, tertiary, and cryptic site |
a
For detailed information about the construction of the mutants see the references cited in column 3, and for sequential classification of sites see Fig. 1.