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. 2024 Oct 1;111(4 Suppl):66–82. doi: 10.4269/ajtmh.24-0313

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© 2024, The author(s)

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Figure 3. — Stage progression and improvement. (A) The number and percentage of participants (ITT collective) who showed LE stage progression at the different follow-up time points divided by the treatment groups. (B) The number and percentage of participants (ITT collective) for the parameter LE stage improvement. (C) Forrest plot (see next page) – multivariable analysis for stage improvement over time. The Forest plot shows the variables that were included in a multivariable logistic regression model (PROC GENMOD) for the time-dependent outcome variable “improvement.” The following covariables were chosen for the model: sex (male/female), age, weight, years in endemic area, treatment (DOX 200/DOX 100/placebo), and region (Kassena Nankana East and Kassena Nankana West) as well as the following time-dependent covariables (taking changes during the follow-up period into account): LE staging (stage 1, 2 or 3), FTS positivity (active LF infection), hygiene status (limb not clean/limb clean), and ADL attack during the previous 6 months (no/yes). Odds ratios (ORs) with 95% CIs are given for each covariable. ADL = adenolymphangitis; DOX = doxycycline; FTS = filariasis test strip; ITT = intention-to-treat; LE = lymphedema; LF = lymphatic filariasis; PROC GENMOD = Procedure for Generalized Linear Models.

Figure 3. — Stage progression and improvement. (A) The number and percentage of participants (ITT collective) who showed LE stage progression at the different follow-up time points divided by the treatment groups. (B) The number and percentage of participants (ITT collective) for the parameter LE stage improvement. (C) Forrest plot (see next page) – multivariable analysis for stage improvement over time. The Forest plot shows the variables that were included in a multivariable logistic regression model (PROC GENMOD) for the time-dependent outcome variable “improvement.” The following covariables were chosen for the model: sex (male/female), age, weight, years in endemic area, treatment (DOX 200/DOX 100/placebo), and region (Kassena Nankana East and Kassena Nankana West) as well as the following time-dependent covariables (taking changes during the follow-up period into account): LE staging (stage 1, 2 or 3), FTS positivity (active LF infection), hygiene status (limb not clean/limb clean), and ADL attack during the previous 6 months (no/yes). Odds ratios (ORs) with 95% CIs are given for each covariable. ADL = adenolymphangitis; DOX = doxycycline; FTS = filariasis test strip; ITT = intention-to-treat; LE = lymphedema; LF = lymphatic filariasis; PROC GENMOD = Procedure for Generalized Linear Models.