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. 2024 Oct;65(10):1626–1632. doi: 10.2967/jnumed.124.267736

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© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: https://jnm.snmjournals.org/page/permissions.

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FIGURE 4. — (A) SPECT/CT imaging 72 h after intravenous administration of ¹¹¹In-1C12-TAT vs. ¹¹¹In-mIgG-TAT (5 MBq, 5 μg) in mice bearing B8484 murine PDAC allografts shows uptake of former but not latter. (B and C) Volume-of-interest analysis of tumor uptake, and tumor-to-blood ratios of ¹¹¹In-1C12-TAT or ¹¹¹In-mIgG-TAT in mice bearing p53^R172H B8484 or p53^null P2FIR allografts, show significant uptake in former, not latter. (D and E) Immunochemistry and Western blot analysis of p53 expression in tumor allograft tissue using rabbit polyclonal anti-p53 antibody CM5 confirmed p53 expression. *P < 0.05. **P < 0.01. %IA = percentage injected activity; H = heart; L = liver; ns = not statistically significant; T = tumor.