Table 2.
Ontology-based clusterization with Metacore
| Biological process | Total | FDR p-value | No of targets | Targets in the dataset |
|---|---|---|---|---|
| Role of cell–cell and ECM-cell interactions in oligodendrocyte differentiation and myelination | 34 | 9.1E−05 | 9 | Claudin-11, PLP1, Connexin 43, Connexin 26, Reticulon 4, MAG, GJC3, Myelin basic protein, Connexin 32 |
| Cell adhesion_Gap junctions | 30 | 1.6E-02 | 6 | PKC, Connexin 43, Connexin 31, Connexin 26, Connexin 32, Tubulin beta |
| Role of Thyroid hormone in regulation of oligodendrocyte differentiation | 48 | 2.6E−02 | 7 | TR-beta, PLP1, p73, MOG, MAG, Myelin basic protein, OATP-A |
| ATM/ATR regulation of G2/M checkpoint | 26 | 3.1E−02 | 5 | Chk1, Chk2, Cyclin B, Claspin, GADD45 beta |
| Substance P-stimulated expression of proinflammatory cytokines via MAPKs | 43 | 3.9E−02 | 6 | PKC-delta, PLC-beta, Substance P extracellular region, CCL13, c-Jun, GRO-2 |
| Oxidative stress_activation of NADPH oxidase | 59 | 3.9E−02 | 7 | PKC, PKC-delta, p47-phox, PLC-beta, p22-phox, TRIO, Rac2 |
| HDL-mediated reverse cholesterol transport | 44 | 3.9E−02 | 6 | Pre beta-1 HDL, Nascent HDL, Large apoE-rich HDL, APOA1, PLTP, APOE |
| Cytoskeleton remodeling | 102 | 5.3E−02 | 9 | Fibronectin, MyHC, MYLK1, MLCK, Collagen I, TGF-beta receptor type I, TRIO, c-Jun, LIMK2 |
The software Metacore was used to perform an ontology-based analysis of the 1060 differentially expressed genes, in order to identify common biological processes and functions. In table the resulting more significant biological processes and the relative associated genes from the experimental dataset are reported. In bold, the biological processes selected for subsequent studies are reported.