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Auto-Abs neutralizing type I IFNs in longitudinal samples. (A–C) Auto-Abs neutralizing IFN-α2 (A), IFN-ω (B), and IFN-β (C), as determined with the luciferase-based neutralization assay, at different time points after infection. Each sample was tested once with an IFN concentration of 100 pg/ml (IFN-α2 and IFN-ω) or 1 ng/ml (IFN-β). I: time of admission to hospital, II: 2 days after admission, III: hospital discharge, and IV: follow-up (1–3 mo).
