TABLE 1.
Study subjectsa
Statistic | Age (yr)b | Viral load (copies/ml)b | CD4 countc | CD8 countc |
---|---|---|---|---|
Mean | 30.9 | 93,873 | 430 | 1,040 |
Median | 30 | 35,082 | 414 | 986 |
Range | 16–52 | <400d–516,175 | 12–1,116 | 61–>2,000e |
Viruses were isolated in 56 of 74 subjects (75.7%). All 56 were of phenotype R5 (0 were of phenotype X4). Of 56 viral isolates, 22 (39.3%) were near full-length genome sequenced. PBMC from 46 study subjects (62.2%) were screened for HIV-1C Gag-specific CTL responses. PBMC from 48 study subjects (64.9%) were screened for HIV-1C Tat-specific CTL responses. PBMC from 47 study subjects (63.5%) were screened for HIV-1C Rev-specific CTL responses. PBMC from 45 study subjects (60.8%) were screened for HIV-1C Nef-specific CTL responses. Samples were randomly selected and screened in sets of 5 to 10 per HIV-1C protein based on PBMC availability and necessity to repeat Elispot assays.
Data were available for all 74 study subjects.
Data were available for 69 of 74 study subjects.
Viral load of <400 copies/ml (four cases) was treated as 400 for calculation purposes.
CD8 count of >2,000 (two cases) was treated as 2,000 for calculation purposes.