Table 2.
The incidence of grades 3-5 toxicities in patients with low SMI and normal SMI.
| All patients (n = 158) | Low SMI (n = 30) | Normal SMI (n = 128) | P-value | |
|---|---|---|---|---|
| Hematological AE | 60 (38%) | 19 (63.3%) | 41 (32.0%) | .001 |
| Anemia | 36 (22.8%) | 16 (53.3%) | 20 (15.6%) | <.001 |
| Neutropenia | 33 (20.9%) | 10 (33.3%) | 23 (18%) | .083 |
| Thrombocytopenia | 12 (7.6%) | 6 (20.0%) | 6 (4.7%) | .004 |
| Neutropenic fever | 12 (7.6%) | 5 (16.7%) | 7 (5.5%) | .037 |
| Non-hematological AE | 67 (42.4%) | 20 (66.7%) | 47 (36.7%) | .003 |
| Hyponatremia | 31 (19.6%) | 10 (33.3%) | 21 (16.4%) | .044 |
| Hypokalemia | 20 (12.7%) | 7 (23.3%) | 13 (10.2%) | .067 |
| Hyperkalemia | 2 (1.3%) | 2 (6.7%) | 0 (0%) | .035 |
| Hypercalcemia | 1 (0.6%) | 1 (3.3%) | 0 (0%) | .190 |
| Creatinine increased | 10 (6.3%) | 3 (10.0%) | 7 (5.5%) | .402 |
| ALT increased | 3 (1.9%) | 0 (0%) | 3 (2.3%) | .662 |
| AST increased | 4 (2.5%) | 1 (3.3%) | 3 (2.3%) | 1.120 |
| Infection | 21 (13.3%) | 9 (30.0%) | 12 (9.4%) | .006 |
| Hand-foot syndrome | 7 (4.4%) | 4 (13.3%) | 3 (2.3%) | .009 |
| Nausea/vomiting | 13 (8.2%) | 4 (13.3%) | 9 (7.0%) | .258 |
| Diarrhea | 15 (9.5%) | 5 (16.7%) | 10 (7.8%) | .136 |
Bold values indicates significant differences.