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. 2024 Jul 3;26(10):1867–1875. doi: 10.1093/neuonc/noae108

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — MGMTp methylation and OS based on cutoff and safety margin. The association of MGMTp methylation with OS in the trial populations, separated into MGMTp methylated (> 1.27), gray zone (−0.28 and 1.27), and truly MGMTp unmethylated patients (<−0.28) as indicated, stratified by treatment and illustrated in Kaplan–Meier plots. A significant difference was observed among the subgroups in the TMZ arms of the pooled Nordic/NOA8 trial (A,P < .0001) and the CE.6 trial (B,P = .0032), respectively (log-rank tests comparing all 3 curves). No differences were observed in the corresponding RT arms (C, D). Pairwise log-rank tests for results with significant OS differences are as follows: (A) Nordic/NOA8 TMZ: methylated versus gray zone, P = .005; methylated versus truly unmethylated, P < .001, gray zone versus truly unmethylated, P = .647. (B) CE.6 RT + TMZ: methylated versus gray zone, P = .618; methylated versus truly unmethylated P = .001; gray zone versus truly unmethylated, P = .096.