Table 1.
Patient’s Baseline Characteristics
| Trial/treatment | Total (N = 687) | ||||
|---|---|---|---|---|---|
| Nordic/NOA8/RT (N = 196) |
Nordic/NOA8/TMZ (N = 133) |
CE.6/RT (N = 175) |
CE.6/RT + TMZ (N = 183) |
||
| N (%) | N (%) | N (%) | N (%) | N (%) | |
| Sex | |||||
| Male | 102 (52.0) | 85 (63.9) | 97 (55.4) | 110 (60.1) | 394 (57.4) |
| Female | 94 (48.0) | 48 (36.1) | 78 (44.6) | 73 (39.9) | 293 (42.6) |
| Age | |||||
| Median | 70.1 | 71.0 | 74.0 | 73.0 | 72.0 |
| Range | 60.5–83.6 | 60.1–83.1 | 65.0–88.0 | 65.0–90.0 | 60.1–90.0 |
| Q1–Q3 | 67.0–73.5 | 67.9–74.9 | 70.0–76.0 | 69.0–76.0 | 68.8–75.0 |
| Age (categorized) | |||||
| ≤70 | 94 (48.0) | 58 (43.6) | 48 (27.4) | 58 (31.7) | 258 (37.6) |
| > 70 | 102 (52.0) | 75 (56.4) | 127 (72.6) | 125 (68.3) | 429 (62.4) |
| Type of surgery | |||||
| Biopsy | 39 (19.9) | 25 (18.8) | 27 (15.4) | 32 (17.5) | 123 (17.9) |
| Resection | 157 (80.1) | 108 (81.2) | 148 (84.6) | 151 (82.5) | 564 (82.1) |
| WHO performance status | |||||
| 0 | 70 (35.7) | 30 (22.6) | 37 (21.1) | 55 (30.1) | 192 (27.9) |
| 1 | 90 (45.9) | 75 (56.4) | 108 (61.7) | 86 (47.0) | 359 (52.3) |
| 2 | 36 (18.4) | 28 (21.1) | 30 (17.1) | 42 (23.0) | 136 (19.8) |
| a MGMT (qMSP) | |||||
| Unmethylated | 100 (51.0) | 86 (64.7) | 96 (54.9) | 93 (50.8) | 375 (54.6) |
| Methylated | 95 (48.5) | 47 (35.3) | 77 (44.0) | 88 (48.1) | 307 (44.7) |
| b Invalid | 1 (0.5) | 0 (0.0) | 2 (1.1) | 2 (1.1) | 5 (0.7) |
| Survival status | |||||
| Alive | 10 (5.1) | 19 (14.3) | 7 (4.0) | 11 (6.0) | 47 (6.8) |
| Dead | 186 (94.9) | 114 (85.7) | 168 (96.0) | 172 (94.0) | 640 (93.2) |
aMGMT-status as reported with original MGMTp methylation classification procedure. 589 patients were reported to have missing or invalid qMSP data, 205 patients in Nordic/NOA8/RT, 180 in Nordic/NOA8/TMZ, 106 in CE.6/RT and 98 CE.6/RT + TMZ.
b5 patients had valid qMSP values, but were classified as invalid using the original MGMTp methylation classification procedure, and could be reclassified using the “corrected” MGMTp methylation ratio (Ratioc).