Fig. 2. Metabolite concentrations in control, PMR, and EORA^neg samples.

a) Comparison of concentrations of significant metabolites identified by ¹H-NMR between control, EORA^neg, PMR at baseline adjusted by DM and sex using Tukey HSD as post-hoc analysis. The overall ANOVA p-value is below the metabolite name, while the p-values for the post-hoc analysis are located between groups. b) Map of metabolic pathways showing metabolites with a p<0.10 obtained from Tukey HSD analysis. Metabolites different in PMR compared to controls are highlighted in blue. Metabolites different in EORA^neg compared to controls are highlighted in orange. Arrows indicate whether the metabolite concentration was higher or lower than in the control group. SG3PC: Sn-Glycero-3-Phosphocholine