Table 3.
Morbidity and mortality rates after liver resection for hepatocellular carcinoma
| Morbidities | All (n=107) | Major resection (n=30) | Minor resection (n=77) | P-value |
|---|---|---|---|---|
| Liver-related morbidities | ||||
| Post-hepatectomy biochemical dysfunction* | ||||
| INR ≥1.5 on or after POD 5 | 7 (6.5) | 3 (10.0) | 4 (5.2) | 0.66 |
| Total bilirubin ≥2.9 mg/dL on or after POD 5 | 4 (3.7) | 1 (3.3) | 3 (3.9) | 0.66 |
| INR ≥1.5 or total bilirubin ≥2.9 mg/dL on or after POD 5 | 11 (10.2) | 4 (13.3) | 7 (9.1) | 0.77 |
| Ascites | 69 (64.5) | 19 (63.3) | 50 (64.9) | 0.99 |
| Surgery-related morbidities | 15 (13.9) | 3 (10.0) | 12 (15.6) | 0.99 |
| Postoperative bleeding | 1 (0.9) | 0 (0.0) | 1 (1.3) | 0.99 |
| Pleural effusion | 7 (6.5) | 2 (6.7) | 5 (6.5) | 0.99 |
| Wound complication | 4 (3.7) | 1 (3.3) | 3 (3.9) | 0.99 |
| Bile leakage | 2 (1.9) | 0 (0.0) | 2 (2.6) | 0.92 |
| Fluid collection | 1 (0.9) | 0 (0.0 | 1 (1.3) | 0.99 |
| Severity grades of surgical complications† | ||||
| Postoperative bleeding | ||||
| Grade 1-2 | 1 (0.9) | - | 1 (1.3) | 0.99 |
| Grade 3 | - | - | - | |
| Grade 4 | - | - | - | |
| Pleural effusion | - | |||
| Grade 1-2 | 1 (0.9) | 1 (1.3) | 0.99 | |
| Grade 3 | 6 (5.6) | 2 (6.7) | 4 (5.2) | |
| Grade 4 | - | - | - | |
| Wound complication | ||||
| Grade 1-2 | 1 (0.9) | 0 (0.0) | 1 (1.3) | 0.99 |
| Grade 3 | 3 (2.8) | 1 (3.3) | 2 (2.6) | |
| Grade 4 | - | - | - | |
| Bile leakage | ||||
| Grade 1-2 | - | - | - | 0.99 |
| Grade 3 | 2 (1.9) | - | 2 (2.6) | |
| Grade 4 | - | - | - | |
| Fluid collection | ||||
| Grade 1-2 | 1 (0.9) | - | 1 (1.3) | 0.99 |
| Grade 3 | - | - | - | |
| Grade 4 | - | - | - | |
| Amount of blood loss | ||||
| <10 mL | 70 (65.4) | 20 (66.7) | 50 (64.9) | |
| 10-100 mL | 30 (28.0) | 9 (30.0) | 21 (27.3) | 0.70 |
| >100 mL | 7 (6.6) | 1 (3.3) | 6 (7.8) | |
| Operation | ||||
| Anesthesia time (minutes) | 250 (219-306) | 270 (205-315) | 245 (220-300) | 0.45 |
| Operation time (minutes) | 217 (181-276) | 242 (175-284) | 215 (182-152) | 0.38 |
| Death | 18 (16.8) | 7 (23.3) | 11 (14.3) | 0.40 |
| 90-day mortality | 0 (0.0) | 0 (0.0) | 0 (0.0) | - |
| 1-year mortality | 0 (0.0) | 0 (0.0) | 0 (0.0) | - |
Values are presented as number (%) or median (interquartile range).
INR, international normalized ratio; POD, postoperative day.
*
POD is greater than on the previous day;
†
Severity grades of surgical complications were defined as the Clavien-Dindo classification.