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Loss of plasminogen-mediated viral growth due to C-terminal mutations in NA. MDBK cells were infected with 100 PFU of the wild-type WSN (●) or mutant WSN-453R (▪) or WSN-453L (▴) virus and incubated in the presence of 0.5 μg of TPCK-trypsin/ml, 0.1% FCS, or 5 μg of human plasminogen/ml. At 0, 12, 24, 48, and 72 h postinfection, virus titers in the culture supernatants were determined.
