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. 2024 Sep 20;15:1354926. doi: 10.3389/fimmu.2024.1354926

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Copyright © 2024 Wu, Wang, Wu, Tao, Li, Zheng, Xu, Du, Zhao, Liang, Xu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular subpopulation profiles with disease severity in acute pancreatitis. (A) Visualization of cellular clusters within the SAP dataset using UMAP dimensionality reduction. (B) Scissor cells identified in the SAP dataset through UMAP dimensionality reduction. Red and blue points correspond to scissor+ and scissor- cells, respectively. (C) Bar chart depicting the quantity and proportion of scissor+ cells across various subgroups. (D) Volcano plots illustrate the DEGs identified in the Mono_c02_IL1B_CCL3 cluster, with upregulated genes marked in red and downregulated genes in blue. (E) Violin plot depicts the expression patterns of DEGs within the Mono_c02_IL1B_CCL3 cluster in SAP patients and healthy controls. (F, G) Main enriched GO and KEGG pathways for significant DEGs in the Mono_c02_IL1B_CCL3 cluster using cluster Profiler. Control: healthy controls, SAP: severe acute pancreatitis.