TABLE 6.

Role of CLAs against cancer.

Year	Probiotic strain	Cancer type	Study subject (cell lines/test animals)	Outcome	References
2006	Bifidobacterium breve	Colon cancer	HT-29, CaCo-2	Suppression of cancer cell proliferation	Coakley et al. (2006)
	VSL-3	Colon cancer	HT-29, CaCo-2	Induction of apoptosis, upregulation of PPARγ expression	Ewaschuk et al. (2006)
2007	Propionibacterium acnes	Colon cancer	SW480	Concentration-dependent growth inhibition of cancer cells, suppression of cell proliferation	Rosberg-Cody et al. (2007)
2009	Bifidobacterium breve NCIMB 702258	Colon cancer	SW480	Suppression of growth of SW480 cells	Coakley et al. (2009)
2016	Pediococcus pentasaceus GS4	Colon cancer	HCT-116	Downregulation of NF-κB and p-Akt, induction of apoptosis, and inhibition of cell proliferation	Dubey et al. (2016)
	Bifidobacterium breve DPC6330	Colon cancer	SW480	Downregulation of Bcl-2 gene expression, suppression of cancer cell proliferation	Hennessy et al. (2016)
	Lactobacillus plantarum	Breast cancer	MDB-MB-231	Suppression of NF-κB pathway, degradation of proteasome of IқBα, upregulation of Bax gene, and release of Cyt-C from mitochondria	Kadirareddy et al. (2016)
2023	Pediococcus pentasaceus GS4	Colon cancer	HCT-116	Reduced expression of COX-2 and 5-LOX, mitochondrial membrane depolarization, and increase in caspase 1p10 expression	Dubey et al. (2023)